The Scientific Philosophy
Targeting Mitochondrial Senescence.
We engineered this multi-phase delivery platform specifically to protect sensitive metabolic substrates from premature oxidative degradation. By
facilitating targeted, in-situ delivery, our system is designed to support the skin's cellular bioenergetic baseline.
Our primary objective is to provide senescent dermal fibroblasts with the exact metabolic fuel they need, aiming to upregulate endogenous ATP
production and help them synthesize structural proteins with optimal efficiency.
The Triple Chamber Architecture
Phase Decoupling & In-Situ Activation
Conventional formulations struggle to preserve high-molecular-weight macromolecules when mixed with physical penetration enhancers.
We solve this through strict physical and chemical compartmentalization. The system utilizes three distinct, highly specialized matrices
that merge exclusively at the precise moment of application.
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Phase 1: Mechanical Poration & Catalytic Shielding
High-purity micro-poration structures are suspended in an advanced, anhydrous thixotropic matrix, ensuring uniform dispersion without
sedimentation. To counter the immediate rush of atmospheric oxygen into the newly formed epidermal micro-channels, we integrated a
noble metal catalytic nano-dispersion into this phase. It acts as a dynamic scavenger, creating a temporary, localized anti-oxidative
micro-vacuum to protect the incoming payload.
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Phase 2: The Bio-Active Energy Core
The core delivers highly sensitive, buffered NAD+ co-encapsulated within ultra-fine phospholipid vesicular nanocarriers. This exogenous
NAD+ works in synergy with targeted metabolic upregulators and an advanced complex of signaling and neuro-mimetic peptides. To prevent
rapid dispersion, we embedded these active liposomes within a recombinant polypeptide structural scaffold, anchoring the bio-actives
precisely over the delivery sites for sustained cellular flux.
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Phase 3: The Biomimetic Lamellar Seal
The final phase features a self-emulsifying system that spontaneously reorganizes into stable lamellar liquid crystals upon contact with the skin. Enriched with a comprehensive biomimetic lipid matrix—including structural Ceramides (NP, AP, EOP) and Phytosphingosine—this phase physically seals the micro-channel orifices. It establishes a unidirectional thermodynamic gradient, forcing the macromolecules downward while instantly preventing Trans-Epidermal Water Loss (TEWL).
Current R&D Status
Ongoing Studies & Laboratory Evaluation
The multi-phase delivery system is currently undergoing rigorous in-vitro evaluation and scale-up optimization. Comprehensive permeation,
stability, and efficacy trials are actively underway in the lab.
While our preliminary models strongly suggest that this phase-isolation approach preserves macromolecule integrity far better than traditional
single-phase emulsions, we are reserving the release of definitive quantitative claims until these ongoing studies are fully concluded.
Protected under Greek Patent Application No. 20260100269.
Let's Collaborate
Strategic B2B Partnerships
We are actively exploring licensing opportunities and strategic collaborations with forward-thinking dermo-cosmetic and pharmaceutical partners.
Due to the proprietary nature of our formulation engineering and sequential activation technology, detailed permeation data, exact chemical structures,
and our complete formulation dossier are available exclusively under a Non-Disclosure Agreement (NDA).
Contact Form
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